File under "no shit" -- if you stay up until 1.30am and wake up at 6.30am, and then try to drive for a couple hundred miles later that day, it's highly unlikely you will enjoy the trip, esp. if 2/3 of it are thru rain so hard you can barely see the highway.
But it's still worth it.
Just finished reading Don't Panic: the Official Hitchhiker's Guide to the Galaxy Companion by Neil Gaiman. Lotsa fun and loaded with odd little bits of HHG ephemera, lore, gossip, etc. Fun fact I think I just learned. In the original BBC radio series (which I've never heard), Arthur Dent's brother is revealed to have been nibbled to death by an okapi. The Damned song "Smash It Up" ends with a loop of a voice saying "nibbled to death by an okapi" which I assume was taken from the radio series. I always wondered where the hell that came from...

Still worth it? I guess so maybe?
My body just wouldn't do that kind of thing. After 30 minutes on the highway, it would pull over and take a nap.
totally depends on who/what is at the end of the trip